Monday, August 22, Injury Series:
It could show how an infection could cause chronic fatigue syndrome, and then seemingly disappear. It focuses on the herpesviruses. Most humans carry several of these herpesviruses in latent form unless some stressor or biological event allows them to become reactivated.
The glial cells perk up remarkably in the presence of viruses, releasing all manner of pro-inflammatory and neuroexcitatory compounds proinflammatory cytokines [IL-1B, IL-6, TNF-a], glutamate, prostaglandins, nitric oxide and free radicals.
All they need to do is tweak the vagus nerve and let it and the brain the do the rest. The Key Component — Glial Cells The glial cells that surround and protect the vagus nerve are the key.
At its most extreme allodyniathe nervous system can interpret even the slightest touch as eliciting pain.
That model of pain production has been solidly documented. Herpesvirus infections of the trigeminal nerve cause shingles. Do herpesvirus infections of the vagus nerve cause chronic fatigue syndrome? What if the vagus nerve receptors were…ceaselessly bombarded with these cytokines?
The symptoms of sickness behavior would be severe and intractable.
Magnetic resonance imaging MRI may be able to detect viral lesions in central nervous system tissues. The severely ill should be given a prominent place in future studies.
Glial cell inhibitors have a good safety profile, have been helpful at curbing neuropathic pain and are not used much in chronic fatigue syndrome or fibromyalgia. If VanElzakker is right then Ibudilast, a drug in clinical trials now for another disorder, is a possibility.
Ibudilast can also prevent viral activation of the microglia. Other general microglial inhibitors exist minocyline, pentoxyfilline, propentfylline but have undesirable side effects. Antivirals Stopping glial cell activation may be easier than getting at the viruses themselves.
Herpesviruses living in the sensory ganglia may be protected from antiviral drugs and antibodies.
One new herpesvirus drug may be coming on the market soon, however. Alternately, viruses other than the herpesviruses could be infecting the vagus nerve.
Behavioral Therapy VanElzakker also notes that while behavioral therapies are not curative and may only apply to a subset of patients, they can help moderate symptoms and improve quality of life in some. Conclusion The VNIT may be able to explain more puzzling aspects of chronic fatigue syndrome than any other.
Next up we talk with Dr.Fideisms Judaism is the Semitic monotheistic fideist religion based on the Old Testament's ( BCE) rules for the worship of Yahweh by his chosen people, the children of Abraham's son Isaac (c BCE)..
Zoroastrianism is the Persian monotheistic fideist religion founded by Zarathustra (cc BCE) and which teaches that good must be chosen over evil in order to achieve salvation. Positive effects Social surrogacy hypothesis. Current research is discovering that individuals suffering from social isolation can employ television to create what is termed a parasocial or faux relationship with characters from their favorite television shows and movies as a way of deflecting feelings of loneliness and social deprivation.
Just as an individual would spend time with a real. The Vagus Nerve Infection Hypothesis could explain alot about chronic fatigue syndrome and could point the way to new treatment possibilities.
ASA College Catalog Download. Current Catalog Volume 31 of the ASA College Catalog is effective as of Fall Semester Define research question and research hypothesis. Explain the difference between a research question and a research hypothesis and describe the appropriate use of each.
Describe the purpose of each and understand the importance of a well-developed question or hypothesis. Provide examples of research questions and research . Introduction The ability to communicate ideas effectively is increasingly recognized as critical to the success of the healthcare system.
Effective communication is required not only for successful interactions between individuals and their health care providers (1) but .